Serrapeptase reviews 2013

This Serrapeptase review highlights all of the highest rated products, as indicated by label rating only. All products are required to be rated in FCC codec SU, or SPU rating only. Enzymes with supplement fact panels rated in IU or mg, are not accepted for comparison. Note: IU "International Units" are not a universally recognized measurement for enzyme activity. For more information on SU, SPU and IU, visit our Serrapeptase Activity Ratings page.


Serrapeptase Activity SPU Breakdown Per Serving.



Strength (activity)


Since enzymes have individual activity levels, we know that a higher weight or milligram value is not an accurate way to determine an item’s strength. Looking at a product label to see the SU, IU, or SPU rating for Serrapeptase, on the other hand, is extremely important. To demonstrate this, the graph to the right indicates both Doctor’s Best Serrapeptase and the Enerex brand (Serrapeptase RX) have 120,000 SPU’s of Serrapeptase activity per capsule. The Enerex capsule contains only 30mg while Doctor's Best contains 500mg. While these capsules are quite different in terms of milligrams, they have exactly the same activity level. The Doctor's Best supplement simply has more filler in it. Therefore, it would be inaccurate to think that you are getting 470 more mg of enzymes because of this difference in weight.




To accurately determine the cost for a particular enzyme, it is best to compare the price per given activity. Our Compare Brands section of this website has broken down the top 5 bestselling brands of Serrapeptase based upon their cost per 100,000 units of activity. This breakdown shows the actual cost of the Serrapeptase you are buying broken down by units of concentration.


Bioavailability and Delivery Methods


There are virtually hundreds of ways to deliver enzymes. For Serrapeptase, there are a handful of common delivery methods including:

  • Hard pressed tablets
  • Encapsulated powders
  • Raw powder
  • Liquid gels


Of the 4 mentioned delivery methods, encapsulated powder remains the leader. Hard pressed tablets are typically heated during the manufacturing process which can decrease the activity of the enzymes, not to mention tablets are much harder to break down in the body. Similarly, raw un-encapsulated powders are hard to mix and deliver, so while powders are cheaper, they are typically not sold because they are simply inconvenient to take on a daily basis. Since enzymes are hydrophilic, they activate in water. Manufacturers have tried to develop liquid gels, but this delivery method is rare. In order to produce liquid gels, rather than using water, the enzymes are mixed with oils to protect their activity. Oil requires longer digestion periods to activate and absorb the enzymes and while the action of oil provides a sustained release, the weight added by the oil suspension leaves less room for the enzymes themselves. In addition, liquid-based enzymes are typically weaker, non-enteric coated or acid resistant and therefore are less desirable delivery method when compared to encapsulated powder.



Understanding Enzyme Activity

Serrapeptase is rated in SPU or serrapeptase units or even serratiopeptidase units. An SPU is equal to SU's, which many companies will simply use interchangeably although the SPU is the more scientifically adopted unit of measurement. This graph indicates the activity of each brand's recommended serving and its associated activity. All enzymes, including Serrapeptase, are rated by the enzyme's corresponding assay method. Enzymes and probiotics are rated differently than vitamins, minerals and other dietary nutraceuticals. Therefore, it would be misleading to describe the potency of enzymes in terms of milligrams. The weight of a product's enzyme component is also independent of its strength. Enzymes have a concentration or activity level to indicate their potency. Furthermore, each enzyme has its own individual assay or test that can be performed to determine its activity. For the nattokinase enzyme, assay tests are conducted in FU's, or Fibrinolytic Units. Serrapeptase is assayed using the SPU or serratiopeptidase units testing method. Since enzymes have a specific activity level, it is not useful to mention milligrams. Therefore 1 gram of Serrapeptase (A) could have only 1/8 the activity of 1 gram of Serrapeptase (B); weight measurements of enzymes are completely independent of the strength.


Enteric Coatings


Many companies use an enteric coating on their enzymes to protect them from stomach acid. Scientific evidence to suggest that Serrapeptase as well as some other systemic enzymes are vulnerable to stomach acid, it was common practice for enzyme manufacturers in the 1950’s to use acid resistant or enteric coatings on the animal-derived enzymes which were available at that time. Bovine (cow) enzymes are released from the digestive tract after the stomach, suggesting that these enzymes would not naturally come in contact with stomach acid. Today companies are finding new and more natural ways to deliver enzymes and protect them from stomach acid without using enteric coatings. Enteric coatings contain undesirable and sometimes banned substances such as plastics. Many companies continue to enteric coat their Serrapeptase powder while others enterically coat their capsules. Enteric coatings limit the body's ability to absorb enzymes because they typically cannot be absorbed until the enteric coating has completely dissolved. HPMCP is among the most common enteric coating used by many companies, which is a combination of vegetable cellulose mixed with plastic. On the other hand, Arthur Andrew Medical’s Serrétia product uses a unique Acid Armor capsule that does not contain any plastic or artificial ingredients. The capsules have a thicker acid resistant shell with a patented locking mechanism that protects the ingredients from stomach acid and premature content leakage. The Acid Armor capsules provide just enough protection from acid to maximize potency and increase bioavailability for absorption. Read more about Acid Armor Capsules