Best Systemic enzyme


Best Serrapeptase Enzyme Blends

The Serrapeptase benefits are well established in scientific research. In particular, cardiovascular health, inflammation and venous thrombosis, respiratory health, and breast engorgement may all be improved upon by combining Serrapeptase with other potent enzymes.


Serrapeptase enzyme blends generally work longer in the body than individual enzyme supplements, and many Serrapeptase enzyme combinations significantly boost the fibrin-dissolving power of this enzyme. This means that a strategically formulated Serrapeptase enzyme blend can ultimately provide more benefits than taking Serrapeptase by itself. However, not all Serrapeptase enzyme blends are created equal.


Neprinol® Versus Vitalzym®

Neprinol and Vitalzym are two of the most popular Serrapeptase enzyme blends on the market. But how do you know which is best? Choosing the best brand is all about comparing the Serrapeptase enzyme content and fibrin-dissolving potential of each product before you buy Serrapeptase enzyme blends. Let's compare Neprinol and Vitalzym head-to-head.

BrandSerrapeptase Activity1
(per dose)
Other Fibrin-Dissolving EnzymesOther IngredientsFillers
Neprinol AFD® 45,000 SPU Nattokinase, Bromelain, Papain, Fungal Protease Lipase, Amla, Rutin, CoQ10 None
Vitalzym (Liquid Gel) 2,500 SPU Bromelain, Papain Lipase, Amla, Rutin, Amylase Medium-chain triglycerides, starch, glycerin, polysacharrides, corn protein, beeswax, glycerin fatty acid ester, soy lecithin, citric acid


As you can see in the chart above, the amount of Serrapeptase contained in one Neprinol® capsule is nearly 20 times more powerful than the Serrapeptase found in Vitalzym®. This is extremely important since most of the clinical Serrapeptase research showing the Serrapeptase benefits used an average dose of 30,000-90,000 SPU per day (the same amount found in two Neprinol capsules). Therefore, even if 100% of the recommended dose of Vitalzym was absorbed by your body, it still would not have enough Serrapeptase enzyme activity to provide the clinical benefits described in Serrapeptase research studies. (For more information on about the importance of SPUs, click here.)


Neprinol also contains several other fibrin-dissolving/anti-inflammatory enzymes and coenzymes, most importantly Nattokinase along with Serrapeptase. Nattokinase is an enzyme extracted from a fermented soybean 'cheese' popular in Japan called Natto [53]. Nattokinase's fibrin-dissolving potential has been tested in more than 12 scientific studies [54], and Nattokinase has been shown to be the most powerful fibrin-degrading enzyme out of more than 200 foods, including bromelain and papain [55]. In fact, Nattokinase has been shown to be more than four times more powerful than human plasmin, which is the enzyme responsible for breaking down fibrin and blood clots in our bodies [56].


Neprinol's powerful one-two punch of Nattokinase and Serrapeptase generally tests well above 30,000 FU (fibrin units) per gram, which means that 30,000 units of fibrin are broken down for each gram of Neprinol powder. Vitalzym, on the other hand, is much less potent since its formula contains less Serrapeptase enzyme activity and no Nattokinase. As a result, Neprinol is often recommended as the best Serrapeptase enzyme blend.