Best Serrapeptase


Serrétia® by Arthur Andrew Medical far surpasses other Serrapeptase products and is our choice for the best overall Serrapeptase product. Our comparisons were based on 4 basic criteria.

  1. Price
  2. Strength
  3. Natural quality
  4. Delivery method

Finding the best priced Serrapeptase product can be a challenging and confusing task. Anyone trying to find quality might choose the Serrapeptase product with the highest sticker price. However, many times the item with the highest sticker price does not always have the highest quality. Our editors have calculated the price per 100,000 Serrapeptase units (SPU)'s of activity for the most popular Serrapeptase products on the market. Serretia® was the lowest priced Serrapeptase of all the major brands costing only 51 cents per 100,000 SPU's of activity. Take a look at the Best Price Serrapeptase graph below to see our results. In addition to being the best priced Serrapeptase, Serretia® surprisingly had the highest strength of Serrapeptase per dose as well. On average, most Serrapeptase products contribute anywhere from 20,000 to 60,000 SPU’s or Serrapeptase units per dose. Serrétia is by far the strongest Serrapeptase product on the market at 250,000 SPU’s per dose. Arthur Andrew Medical uses Serrapeptase in virtually all of their formulations. Serrapeptase is one of the most medically universal enzymes available. Clinical studies show that this enzyme reduces arterial plaque, inflammation, fibrin and blood clots. Serrapeptase also treats sinus infections and is one of the best natural decongestants. Please find our Highest Strength Serrapeptase graph below to see our results.


Arthur Andrew Medical® blends several thousand kilograms of Serrapeptase per year allowing them to manufacture the enzymes significantly cheaper. Arthur Andrew normally stocks Serrapeptase with different levels of activity and is available for private label manufacturing. All raw materials are naturally BPA and phthalate (plastic) free, and come in Acid Armor capsules for 100% natural protection. Enterically coated powders and capsules are available for an additional cost.


Best Price Serrapeptase: 

Price per 100,000 SPU's has been calculated based on the Manufacturer's listed MSRP.

The graph above indicates the cost of Serrapeptase per 100,000 Serrapeptase Units. At retail, the least expensive brand of Serrapeptase is Serrétia, manufactured by Arthur Andrew Medical with the most expensive brand being Solaray.

This graph also demonstrates the cost per 100,000 SPU's of Serrapeptase activity.

The Arthur Andrew Medical brand of Serrapeptase (Serrétia), demonstrates the lowestcost in comparison to the most popular brands. Serrétia is extremely impressive as it was not only the strongest Serrapeptase, but also the cheapest in terms of cost. Out of all of the major brands that were compared, Serrétia was the only brand that did not use HPMCP (Hydroxypropyl Methylcellulose Phthalate) in the manufacturing process.


Highest Strength Serrapeptase (per dose)


Choosing a Serrapeptase enzyme supplement is not always easy. Although most supplements claim that they provide numerous Serrapeptase benefits, such as reducing inflammation, preventing blood clots and dissolving scar tissue, not all of them perform the same way. Therefore, whether you are considering using Serrapeptase for prevention, treatment or pain relief, it is extremely important to choose the best Serrapeptase enzyme brand. If you expect to simply pay more to get a higher quality Serrapeptase, you may be disappointed. In certain cases the retail cost of a product depends on the relationship between the vendor and the manufacturer. If the vendor is buying directly from the manufacturer the price is usually more affordable than if that vendor is buying from a middleman.


Delivery Method


Instead of using any type of enteric-coated Serrapeptase, the Serrapeptase supplement Serretia® uses a different technology known as Acid Armor®. Acid Armor capsules are made of an extra-thick layer of cellulose (the main component of veggie caps) with a micro-threaded locking mechanism that seals the two sides of the capsules together tightly, limiting premature rupture of the capsule's contents. Acid Armor capsules have also been designed to delay the release of the capsule's contents for up to an hour. When a product like Serrétia is taken on an empty stomach, the capsule enters and leaves the stomach in 30 minutes or less. This means that the Acid Armor provides more than enough time for the Serrapeptase enzyme to get through the stomach and into the more "enzyme friendly" environment of the intestines.


In addition, Serrapeptase capsules themselves do not cause the stomach to start producing acid when they are taken on an empty stomach. Acid production normally occurs when the stomach fills with food and its lining is stretched. Therefore, any tests that supposedly "prove" the necessity of enteric-coated Serrapeptase by exposing enzymes to extremely acidic environments for several hours do not accurately demonstrate the actual, real-life conditions in an empty stomach!


Acid Armor vs Enteric Coating


For years there has been the belief that Serrapeptase and other systemic enzymes will be destroyed by acid in the stomach if they are not protected. According to the companies that circulate this belief, the only way to shield Serrapeptase from destruction is to use enteric coating. Enteric coatings are made from plastics and other chemicals. The most common methods are enterically coated capsules and enterically coated raw enzyme powders. This is supposed to protect the enzymes from stomach acids and release them into the intestines. However, there are currently no clinical studies that demonstrate this effect. Arthur Andrew Medical designed Acid Armor capsules to deliver enzymes precisely outside of the stomach in the intestines, rather than mixing enterically coated enzymes with acid in the stomach and hoping that they survive.


While it is true that certain enzymes, usually those derived from animals, become less active in very acidic environments, our testing has revealed that enteric coating can prevent proper absorption and can limit bioavailability. After conducting a series of third-party tests, it was observed that products containing enteric-coated Serrapeptase powder lost more activity than supplements using non-enteric-coated Serrapeptase powder. Raw food diets contain high levels of natural enzymes, not enteric coated enzymes. These enzymes have evolved to survive a wide range of different pH levels. Therefore, enteric coatings are only important (in theory) for animal-based enzymes that are naturally released in the digestive tract after leaving the stomach. Animal pancreatic enzymes were designed by nature to survive a limited pH range.


BrandSerrapeptase Activity1
(per dose)
Serrétia™ 250,000 SPU Acid Amor® capsule
Doctor’s Best Serrapeptase 80,000 IU Enteric-coated capsules
Serra Enzyme™ 160,000 IU Enteric-coated capsules
Source Naturals Serrapeptase 120,000 SPU Enteric-coated capsules
Solaray Serrapeptase 40,000 IU Enteric-coated capsules
Vitamin Shoppe Serrapeptase 80,000 SPU Enteric-coated capsules
Serra RX Serrapeptase 160,000 SPU Enteric-coated powder Serrapeptase
  1. SPU = Serratio Peptidase Units; IU = International Unit. Click on the following link to find out more about measuring and comparing Serrapeptase enzyme strength. Click Here to understand SU's, SPU's and IU's.
  2. There is a lot of inaccurate information on the web about the benefits of enteric-coated Serrapeptase. Click here to learn more about Acid Armor versus Enteric Coating.